81377 München christian.haass(at)dzne.de +49 89 4400-46549 Areas of investigation/research focus Professor. Haass started to work on Alzheimer's disease (AD) in 1990 at a time, when very little welches known about the cellular mechanisms involved. Based on the pathology, which shows invariably the accumulation and deposition of Amyloid ß-peptide (Aß), he focused his work on the generation and metabolism of Aß. Christian Haass hypothesized against the widely accepted general opinion hinein this field that Aß may Beryllium produced from its precursor hinein a physiologically gewöhnlich pathway and not necessarily in a pathological process. Indeed he found by using very simple tissue culture systems that Aß is produced and liberated under physiological conditions. This pivotal finding welches a major breakthrough for the entire field, since it allowed elucidating the molecular principles behind Aß generation as well as the identification of the enzymes (the so-called secretases) involved hinein generation and liberation of the peptide and finally the development of selective inhibitors to therapeutically lower Aß production hinein patients.
Functional cookies help to perform certain functionalities like sharing the content of the website on social media platforms, collect feedbacks, and other third-party features. Performance Performance
You want to get your driving licence hinein Munich as soon as possible, hinein an enjoyable and straightforward way? If so, you’ve come to exactly the right place! We are a Munich driving school and guarantee you all-round support hinein theory, practice and other aspects of Schulung.
We work on the molecular and cellular mechanisms of neurodegeneration with a strong focus on Alzheimer’s disease and related disorders. We are searching for therapeutic targets within the amyloid cascade. Secretases, amyloid metabolism and microglial function are within the focus of ur research.
Was ich am besten fand artikel die Fahrstunden mit Joachim, wirklich ein toller Fahrlehrer bei dem du wirklich Dasjenige Gefühl bekommst Dasjenige es ihn spaß macht dir Dasjenige alles beizubringen. Wurde es ans herz legen An dieser stelle dein copyright zu machen ansonsten sobald es m…
Every driving school must display a Streich of the prices for each individual item. Our prices can be found at "Prices / Cost calculator". Individual price information is also supplied on the telephone.
Inhibition of secretases as a therapeutic approach requires detailed knowledge about the physiological functions and biochemical properties of these enzymes to avoid unwanted side effects. Christian Haass welches the first to demonstrate a physiological function for beta-secretase. He showed that this protease is critically required for the regulation of myelination. Furthermore, he identified a novel APP processing pathway, which welches overlooked for more than 20 years and which has strong implications for clinical trials using beta-secretase inhibitors. He was also the first to identify the highly complicated subunit composition of gamma-secretase. All these findings not only helped to understand several signaling pathways critically involved in brain development (such as myelination and cell differentiation) but also haass provided the Stützpunkt for several current therapeutic approaches.
Analytical cookies are used to understand how visitors interact with the website. These cookies help provide information on metrics the number of visitors, bounce rate, traffic source, etc. Advertisement Advertisement
Refresher driving lessons COURSES Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua
Together with an interdiziplinary team he uncovered the molecular mechanisms of Alzheimer's disease and identified target molecules for therapeutic treatment.
Der markante Bau mit den drei hohen Türmen wurde aus massiven Sandsteinblöcken erbaut des weiteren besitzt eine dekorative Rosette des weiteren ein Giebeldach.
The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not Endbenutzer has consented to the use of cookies. It does not store any Privat data.
Fein: Ich habe leider nicht an meine Termin erscheinen zumal nehme ich komplett Verantwortung aber habe ich erwartet Dasjenige nach minderst die Hälfte oder eine Gutschein erwartet leider habe ich meine Nachtgebet Geld verloren.
At the earliest, approx. 3 – 5 months before your 18th birthday, depending on whether you wish to do the theoretical and the practical training one after the other or at the same time.
We also use third-party cookies that help us analyze and understand how you use this website. These cookies will Beryllium stored hinein your browser only with your consent. You also have the Vorkaufsrecht to opt-out of these cookies. But opting out of some of these cookies may affect your browsing experience.